Pyridine → HCID 12944902、化合物

HRID 1578266ノート

反応式

HRID 1578266 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1Cl)[N:8]([CH2:13][CH3:14])[CH:7]=[C:6]([C:15]([OH:17])=[O:16])[C:5]2=[O:18].[C:19]1([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.N1C=CC=CC=1>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N:28]1[CH2:29][CH2:30][N:25]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:26][CH2:27]1)[N:8]([CH2:13][CH3:14])[CH:7]=[C:6]([C:15]([OH:17])=[O:16])[C:5]2=[O:18]

参加物

5

反応物 3

HCID 1049PyridineHCID 70961-PhenylpiperazineHCID 127338866,7-Dichloro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

生成物 1

HCID 12944902HCID 12944902、化合物収率 54.9%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2.15 g of 6,7-dichloro-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, 6.5 g of 1-phenylpiperazine and 20 cm3 of pyridine were heated under reflux for 16 hours. The solvent was removed in vacuo and the residue was taken up in 20 cm3 of water. The suspension obtained was stirred and brought to pH 7 by the addition of acetic acid. The solid was filtered off and recrystallised from methyl cellosolve. 1.7 g of 6-chloro-1-ethyl-4-oxo-7-(4-phenylpiperazinyl)-1,4-dihydro-quinoline-3-carboxylic acid, m.p. 234°-235° C., were obtained.

後処理

  1. temperatureunder reflux for 16 hours
  2. customThe solvent was removed in vacuo
  3. customThe suspension obtained
  4. filtrationThe solid was filtered off
  5. customrecrystallised from methyl cellosolve

出典と根拠

ORDレコード
ord-9fb47b30be1144629b35bdc98ebc312d
出典データセット
uspto-grants-1981_09
特許番号
US04292317

反応ノート

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