Water → (2-Phenyl-1H-imidazol-5-yl)methanol
反応式
[C:1]1([C:7]2[NH:8][CH:9]=[C:10]([C:12](O)=[O:13])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)([O-])[O-].[Na+].[Na+].O>C=O.O1CCOCC1>[C:1]1([C:7]2[NH:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
6
実験手順
To a suspension of 1.88 g (0.01 mol) of 2-phenylimidazole-4-carboxylic acid in a mixture of 3 ml of ~37% formaldehyde and 3 ml of 1,4-dioxane is added 2.1 g (0.02 mol) of sodium carbonate, and the resultant mixture is heated at 60°-70° C. for 5 hours, with stirring. After completion of the reaction, 5 ml of water is added, and the mixture is allowed to stand for 2 hours, on cooling. The resultant solid is recovered by filtration and recrystallized from ethyl acetate and filtered to afford 2-phenyl-4-hydroxymethylimidazole as a solid, m.p.168°-170° C.
後処理
- additionis added
- temperatureon cooling
- filtrationThe resultant solid is recovered by filtration
- customrecrystallized from ethyl acetate
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-e2db78945aea4502871cfff6e8518116
- 出典データセット
- uspto-grants-1981_09
- 特許番号
- US04292431
反応ノート
読み込み中…