Formaldehyde → (1-(propan-2-yl)-1H-imidazol-5-yl)methanol
反応式
[CH:1]([N:4]1[C:8]([C:9](OC)=[O:10])=[CH:7][N:6]=[CH:5]1)([CH3:3])[CH3:2].[OH-].[Na+].C=O>O>[CH:1]([N:4]1[C:8]([CH2:9][OH:10])=[CH:7][N:6]=[CH:5]1)([CH3:3])[CH3:2]参加物
5
実験手順
1.68 g (0.01 mol) of 1-isopropyl-5-carbmethoxyimidazole is suspended in 5 ml of water. To the suspension are added 0.8 g (0.02 mol) of sodium hydroxide and 4 ml of ~37% aqueous formaldehyde. The resultant mixture is heated to reflux for 2 hours. After completion of the reaction, the solvent is stripped off, and the residue is extracted with ethyl acetate and concentrated to give 1-isopropyl-5-hydroxymethylimidazole as a solid, m.p. 83°-84° C.
後処理
- temperatureto reflux for 2 hours
- customAfter completion of the reaction
- extractionthe residue is extracted with ethyl acetate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-cc3f4e498c0f4806bdb4cb2e6c05c24c
- 出典データセット
- uspto-grants-1981_09
- 特許番号
- US04292431
反応ノート
読み込み中…