Acetohydrazide → HCID 12207321、化合物

HRID 1578525ノート

反応式

HRID 1578525 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]=[C:10]=[S:11].[C:12]([NH:15][NH2:16])(=[O:14])[CH3:13]>C1COCC1>[C:12]([NH:15][NH:16][C:10]([NH:9][C:3]1[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=1[Cl:1])=[S:11])(=[O:14])[CH3:13]

参加物

4

反応物 2

HCID 14039AcetohydrazideHCID 227520811-Chloro-2-isothiocyanato-4-methylbenzene

生成物 1

HCID 12207321HCID 12207321、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

One tenth mole, 18.3 g., of 2-chloro-5-methylphenylisothiocyanate and 11.0 g. (0.15 mole) of acetylhydrazine were refluxed for 7 hours in 500 ml. of THF. After cooling, the insoluble product was collected by filtration. The crude product was collected by filtration. The crude product was washed with water, filtered and dried. The yield was 25 g. of 1-acetyl-4-(2-chloro-5-methylphenyl)-3-thiosemicarbazide, m.p. about 145°-157°C.

後処理

  1. temperatureAfter cooling
  2. filtrationthe insoluble product was collected by filtration
  3. filtrationThe crude product was collected by filtration
  4. washThe crude product was washed with water
  5. filtrationfiltered
  6. customdried

出典と根拠

ORDレコード
ord-f7ce56690b79492bbcd3f8d93e8101d4
出典データセット
uspto-grants-1976_02
特許番号
US03937713

反応ノート

読み込み中…