Sodium Hydroxide → 4-[4-(Oxiran-2-ylmethoxy)phenyl]-1,2,3-thiadiazole

HRID 1579050

反応式

HRID 1579050 の反応式
[OH-].[Na+].[OH:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[N:12][S:13][CH:14]=2)=[CH:6][CH:5]=1.[CH2:15]([CH:17]1[O:19][CH2:18]1)Br>O>[O:19]1[CH2:18][CH:17]1[CH2:15][O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:11]=[N:12][S:13][CH:14]=2)=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 18430EpibromohydrinHCID 27968604-(1,2,3-Thiadiazol-4-Yl)Phenol

生成物 1

HCID 27371034-[4-(Oxiran-2-ylmethoxy)phenyl]-1,2,3-thiadiazole

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 0.112 g. of sodium hydroxide in 10 ml. of water is added 0.499 g. of 4-(4-hydroxyphenyl)1,2,3-thiadiazole and to the resulting solution is added dropwise, under stirring, 0.66 ml. of epibromohydrin, in a 5 minute period. The reaction mixture is stirred for 48 hours and extracted several times with ethyl acetate. The combined organic extracts are washed with water to neutrality, dried over anhydrous sodium sulfate and evaporated to dryness under vacuo. The semisolid residue is crystallized from methylene chloride-hexane to yield the pure 4-[4(2,3-epoxypropoxy)phenyl] 1,2,3-thiadiazole.

後処理

  1. stirringThe reaction mixture is stirred for 48 hours
  2. extractionextracted several times with ethyl acetate
  3. washThe combined organic extracts are washed with water to neutrality
  4. dry with materialdried over anhydrous sodium sulfate
  5. customevaporated to dryness under vacuo
  6. customThe semisolid residue is crystallized from methylene chloride-hexane

出典と根拠

ORDレコード
ord-f391237350f5492a937ff261322763b3
出典データセット
uspto-grants-1976_02
特許番号
US03940407

関連ノート

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