Dimethylcarbamoyl Chloride → alpha-Diethylcarbamylthio-6-methoxy-2-naphthylacetic acid

HRID 1579843

反応式

HRID 1579843 の反応式
[CH2:1]([N:3]([CH2:7][CH3:8])[C:4](Cl)=[O:5])[CH3:2].C(Cl)(=O)N.C(NC(Cl)=O)C.CN(C)C(Cl)=O.C([S:28][CH:29]([C:33]1[CH:42]=[CH:41][C:40]2[C:35](=[CH:36][CH:37]=[C:38]([O:43][CH3:44])[CH:39]=2)[CH:34]=1)[C:30]([OH:32])=[O:31])(=O)N.C(NC(SC(C1C=CC2C(=CC=C(OC)C=2)C=1)C(O)=O)=O)C.CN(C)C(SC(C1C=CC2C(=CC=C(OC)C=2)C=1)C(O)=O)=O>>[CH2:1]([N:3]([CH2:7][CH3:8])[C:4]([S:28][CH:29]([C:33]1[CH:42]=[CH:41][C:40]2[C:35](=[CH:36][CH:37]=[C:38]([O:43][CH3:44])[CH:39]=2)[CH:34]=1)[C:30]([OH:32])=[O:31])=[O:5])[CH3:2]

参加物

8

反応物 7

HCID 6598Dimethylcarbamoyl ChlorideHCID 6916Diethylcarbamoyl chlorideHCID 68048Carbamic chlorideHCID 12321963N-ethylcarbamoyl chlorideHCID 21569102alpha-Carbamylthio-6-methoxy-2-naphthylacetic acidHCID 21569125alpha-Dimethylcarbamylthio-6-methoxy-2-naphthylacetic acidHCID 86732901alpha-Ethylcarbamylthio-6-methoxy-2-naphthylacetic acid

生成物 1

HCID 21569122alpha-Diethylcarbamylthio-6-methoxy-2-naphthylacetic acid

実験手順

When diethylcarbamylchloride is replaced in the above procedure by carbamyl chloride (prepared in situ from potassium cyanate and anhydrous hydrogen chloride in anhydrous chloroform), ethylcarbamyl chloride or dimethylcarbamyl chloride, then the products prepared are α-carbamylthio-6-methoxy-2-naphthylacetic acid, α-ethylcarbamylthio-6-methoxy-2-naphthylacetic acid or α-dimethylcarbamylthio-6-methoxy-2-naphthylacetic acid.

後処理

  1. customthe products prepared

出典と根拠

ORDレコード
ord-223595e68bfe40c3bf6bc68e0ad04983
出典データセット
uspto-grants-1976_01
特許番号
US03931269

関連ノート

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