Ammonia → 5-(3,4-Dichlorobutyl)pyridine-2-carboxamide

HRID 1580974ノート

反応式

HRID 1580974 の反応式
[Cl:1][CH:2]([CH2:14][Cl:15])[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11](O)=[O:12])=[N:9][CH:10]=1.S(Cl)(Cl)=O.C(Cl)(Cl)Cl.[NH3:24]>C1C=CC=CC=1>[Cl:1][CH:2]([CH2:14][Cl:15])[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([NH2:24])=[O:12])=[N:9][CH:10]=1

参加物

6

反応物 4

HCID 222AmmoniaHCID 6212ChloroformHCID 24386Thionyl ChlorideHCID 2181975-(3,4-Dichlorobutyl)pyridine-2-carboxylic acid

生成物 1

HCID 132718785-(3,4-Dichlorobutyl)pyridine-2-carboxamide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

10 g of 5-(3,4-dichlorobutyl)picolinic acid was added to the solution of thionyl chloride (30 ml) and chloroform (100 ml), and resulting solution was refluxed for fifteen minutes. The reaction mixture was evaporated in reduced pressure to obtain oily residue. This was dissolved in 100 ml of benzene and treated with 28% aqueous ammonia (50 ml) at 4° - 10°C with vigorous stirring for an hour. Benzene extract was evaporated in reduced pressure to give crude product as solid.

後処理

  1. customresulting solution
  2. temperaturewas refluxed for fifteen minutes
  3. customThe reaction mixture was evaporated in reduced pressure
  4. customto obtain oily residue
  5. extractionBenzene extract
  6. customwas evaporated in reduced pressure
  7. customto give crude product as solid

出典と根拠

ORDレコード
ord-199681186ad64a948c28d562c5d279a8
出典データセット
uspto-grants-1976_01
特許番号
US03935221

反応ノート

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