Tetrahydrofuran → HCID 11118078、化合物

HRID 1581649ノート

反応式

HRID 1581649 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[C:10]2[S:14][C:13](=[O:15])[NH:12][C:11]2=[O:16])=[CH:5][CH:4]=1.O1CCCC1>[Pd].C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH:10]2[S:14][C:13](=[O:15])[NH:12][C:11]2=[O:16])=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 2331125-(4-Methoxybenzylidene)-thiazolidine-2,4-dione

生成物 1

HCID 11118078HCID 11118078、化合物収率 97%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

5-[(4-Methoxyphenyl)methylidene]thiazolidine-2,4-dione (6.00 g, 25.5 mmol), 10% palladium on carbon (6.00 g) and a mixed solvent of tetrahydrofuran and ethanol (2:1 v/v, 300 mL) were mixed, and hydrogenation was performed at room temperature and at an initial pressure of 294 kPa. After completion of the reaction, catalyst was filtered and the filtrate was concentrated. The residue was purified by silica gel chromatography (eluate n-hexane: ethyl acetate=2:1 v/v) to obtain 5.84 g (97%) of the title compound as colorless powder.

後処理

  1. customwas performed at room temperature
  2. customAfter completion of the reaction, catalyst
  3. filtrationwas filtered
  4. concentrationthe filtrate was concentrated
  5. customThe residue was purified by silica gel chromatography (eluate n-hexane: ethyl acetate=2:1 v/v)

出典と根拠

ORDレコード
ord-5061c0be22b4472e954f66723d78019f
出典データセット
uspto-grants-2004_05
特許番号
US06730687B1

反応ノート

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