2-Methoxyethylamine → methyl 5-[N-acetyl-N-(2-methoxyethyl)amino]-4,7-dihydro-6-(2-methoxyethyl)amino-4,7-dioxobenzo[b]thiophene-2-carboxylate

HRID 1582195ノート

反応式

HRID 1582195 の反応式
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[C:6]([N:9]([C:14]1[C:15](=[O:28])[C:16]2[CH:20]=[C:19]([C:21]([O:23][CH3:24])=[O:22])[S:18][C:17]=2[C:25](=[O:27])[CH:26]=1)[CH2:10][CH2:11][O:12][CH3:13])(=[O:8])[CH3:7]>O1CCCC1>[C:6]([N:9]([C:14]1[C:15](=[O:28])[C:16]2[CH:20]=[C:19]([C:21]([O:23][CH3:24])=[O:22])[S:18][C:17]=2[C:25](=[O:27])[C:26]=1[NH:5][CH2:4][CH2:3][O:2][CH3:1])[CH2:10][CH2:11][O:12][CH3:13])(=[O:8])[CH3:7]

参加物

4

反応物 2

HCID 80182-MethoxyethylamineHCID 12987500methyl 5-[N-acetyl-N-(2-methoxyethyl)amino]-4,7-dihydro-4,7-dioxobenzo[b]thiophene-2-carboxylate

生成物 1

HCID 22719980methyl 5-[N-acetyl-N-(2-methoxyethyl)amino]-4,7-dihydro-6-(2-methoxyethyl)amino-4,7-dioxobenzo[b]thiophene-2-carboxylate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

2-Methoxyethylamine (0.15 ml) was added to a solution of methyl 5-[N-acetyl-N-(2-methoxyethyl)amino]-4,7-dihydro-4,7-dioxobenzo[b]thiophene-2-carboxylate (0.39 g) in tetrahydrofuran (30 ml) and the mixture was stirred at room temperature for 6.5 hours. The solvent was evaporated and the residue was purified by silica gel column chromatography (elution with hexane-ethyl acetate 50:1 solution) to give methyl 5-[N-acetyl-N-(2-methoxyethyl)amino]-4,7-dihydro-6-(2-methoxyethyl)amino-4,7-dioxobenzo[b]thiophene-2-carboxylate (0.39 g) as a reddish purple oil.

後処理

  1. customThe solvent was evaporated
  2. customthe residue was purified by silica gel column chromatography (elution with hexane-ethyl acetate 50:1 solution)

出典と根拠

ORDレコード
ord-e414575204514a368c714cc5f88fa0ae
出典データセット
uspto-grants-2004_05
特許番号
US06734203B2

反応ノート

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