Thionyl Chloride → 5-(Chloromethyl)-1,2-oxazole-3-carbonyl chloride

HRID 1582904ノート

反応式

HRID 1582904 の反応式
[Cl:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([C:8]([OH:10])=O)[CH:4]=1.S(Cl)([Cl:13])=O>N1C=CC=CC=1>[Cl:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([C:8]([Cl:13])=[O:10])[CH:4]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 218664495-(Chloromethyl)-1,2-oxazole-3-carboxylic acid

生成物 1

HCID 130018995-(Chloromethyl)-1,2-oxazole-3-carbonyl chloride

試薬・触媒・溶媒 1

HCID 1049Pyridine触媒

実験手順

120 g (743 mmol) of 5-chloromethylisoxazole-3-carboxylic acid together with 500 ml of thionyl chloride and 2 drops of pyridine were refluxed for 10 hours, subsequently concentrated in vacuo and then distilled at 20 torr. The product distilled at 125-1330C. 78 g resulted (58% of theory)

後処理

  1. concentrationsubsequently concentrated in vacuo
  2. distillationdistilled at 20 torr
  3. distillationThe product distilled at 125-1330C
  4. custom78 g resulted (58% of theory)

出典と根拠

ORDレコード
ord-2b4f043b2efb43f18b7896ab286d7cfb
出典データセット
uspto-grants-2004_05
特許番号
US06740647B1

反応ノート

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