Anthranilic Acid → N-Methylanthranilic acid

HRID 1583248

反応式

HRID 1583248 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:11]=O.[H][H]>C(O)C.[Pt]=O>[CH3:11][NH:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

6

反応物 3

HCID 227Anthranilic AcidHCID 712FormaldehydeHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 67069N-Methylanthranilic acid

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

A solution of 2-aminobenzoic acid (25 g) in ethanol (300 ml) reacted with an excess of paraformaldehyde and then reduced with hydrogen gas at 60 psi over platinum oxide (25 g) catalyst. After hydrogen uptake ceased, the mixture was filtered and the solvent removed on a rotary evaporator. The product was purified by chromatography on silica gel and the structure confirmed by nmr and infrared analysis.

後処理

  1. filtrationthe mixture was filtered
  2. customthe solvent removed on a rotary evaporator
  3. customThe product was purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-ed246f2e1c7046a1a8e4929d902ad398
出典データセット
uspto-grants-1985_11
特許番号
US04551279

関連ノート

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