Nitric Acid → HCID 13535751、化合物
反応式
[N+:1]([O-:4])([OH:3])=[O:2].C(OC(=O)C)(=O)C.O[C@@H:13]1[CH2:17][C:16](=[O:18])[C:15]([CH2:19][CH:20]=[CH2:21])=[C:14]1[CH3:22]>C(Cl)(Cl)Cl>[CH3:22][C:14]1[C@H:13]([O:2][N+:1]([O-:4])=[O:3])[CH2:17][C:16](=[O:18])[C:15]=1[CH2:19][CH:20]=[CH2:21]参加物
5
実験手順
Into a mixed solution of 8 g of fuming nitric acid and 24 g of acetic anhydride, kept at a temperature of -5° to 10° C. was added dropwise 6 g of (R)-4-hydroxy-3-methyl-2-(2-propenyl)-2-cyclopenten-1-one ([α]D24 : -7.81° (C=1.07, in chloroform), (R)-isomer/(S)-isomer=77.4/22.6). Thereafter, with the same operations as in Example 1, 7.50 g of crude (R)-3-methyl-4-nitroxy-2-(2-propenyl)-2-cyclopenten-1-one was obtained.
後処理
- customkept at a temperature of -5° to 10° C.
出典と根拠
- ORDレコード
- ord-47594a5fed934e4f99d64cc4a3f435ca
- 出典データセット
- uspto-grants-1985_11
- 特許番号
- US04552703
反応ノート
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