Acetonitrile → HCID 70133040、化合物

HRID 1584669ノート

反応式

HRID 1584669 の反応式
C(O[C:9](=[O:26])[CH2:10][N:11]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)C1C=CC=CC=1.[C:27](#[N:29])[CH3:28].[NH2-].[Na+].[CH2:32]([Mg]Cl)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>CC(OC)(C)C>[NH2:29][C:27]([CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[CH:28][C:9](=[O:26])[CH2:10][N:11]([CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

参加物

6

反応物 4

HCID 6342AcetonitrileHCID 24533Sodium amideHCID 4683020Glycine, N,N-bis(phenylMethyl)-, phenylMethyl esterHCID 178418336HCID 178418336、化合物

生成物 1

HCID 70133040HCID 70133040、化合物

試薬・触媒・溶媒 1

HCID 15413tert-Butyl methyl ether溶媒

実験手順

The title compound was prepared from N,N-dibenzyl-glycine benzyl ester, 54 mmole, and 3.3 mL, 64 mmole of acetonitrile. Following the procedure described in Example 2 the ester and nitrile mixture was added to 5.5 g, 127 mmole of sodium amide in MTBE. After solvent removal, benzyl magnesium chloride (PhCH2MgCl 145 mmole) was added following the procedure in Example 2. The resulting enamine was purified by chromatography, following the procedure described in Example 4. The yield of enamine was 22.3 g (50 mmole, 78%).

後処理

  1. additionwas added
  2. customThe resulting enamine was purified by chromatography

出典と根拠

ORDレコード
ord-e1a3f166e29044b39a9dbf6ecb2f6839
出典データセット
uspto-grants-1999_08
特許番号
US05932766

反応ノート

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