3-Nitrophenylethyl alcohol → 2-(3-Aminophenyl)ethan-1-ol

HRID 15859

反応式

HRID 15859 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][OH:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][OH:12])[CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 2

HCID 1040583-Nitrophenylethyl alcoholHCID 2723923Ammonium formate

生成物 1

HCID 149389872-(3-Aminophenyl)ethan-1-ol収率 54%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

2-(3-Nitrophenyl)ethanol (836 mg, 5.00 mmol) and Pd (10% on charcoal, 200 mg) were suspended in dry methanol (10 mL). After the addition of ammonium formate (1.450 g, 23 mmol) a slightly exothermic and effervescent reaction was observed. After stirring for 1 h at room temperature the mixture was filtered over celite. The filtrate was evaporated and the residue dissolved in ethyl acetate. After washing with saturated aqueous sodium hydrogencarboante solution, water and brine the organic layer was dried (magnesium sulfate) and the solvent removed under reduced pressure affording the title compound in 54% yield (373 mg) as a white solid.

後処理

  1. customeffervescent reaction
  2. filtrationwas filtered over celite
  3. customThe filtrate was evaporated
  4. dissolutionthe residue dissolved in ethyl acetate
  5. washAfter washing with saturated aqueous sodium hydrogencarboante solution, water and brine the organic layer
  6. dry with materialwas dried (magnesium sulfate)
  7. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-824ab447f90a413daf02962ad5f273a6
出典データセット
uspto-grants-2010_06
特許番号
US07732600B2

関連ノート

読み込み中…