Sodium borohydride → 4-(2-Hydroxyethoxy)-6,6'-dimethyl-2,2'-bipyridine
反応式
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[N:14]=2)[N+:8]([O-])=[C:9]([CH3:11])[CH:10]=1.[BH4-].[Na+]>CO.[Pd]>[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[C:9]([CH3:11])[N:8]=[C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[N:14]=2)[CH:6]=1参加物
5
実験手順
4-(2-hydroxyethoxy)-6,6'-dimethyl-2,2'-bipyridine-N-oxide (23) (2.40 g, 9.22 mmoles) was dissolved in methanol (75 ml). 10% palladium on carbon (0.54 g) was added and then slowly sodium borohydride (3.24 g, 85.6 mmoles). Palladium on carbon was filtered out and the solvent was evaporated. The product was purified by means of flash chromatography (silica, 5-50% methanol/chloroform).
後処理
- filtrationPalladium on carbon was filtered out
- customthe solvent was evaporated
- customThe product was purified by means of flash chromatography (silica, 5-50% methanol/chloroform)
出典と根拠
- ORDレコード
- ord-50da65f52c124b6ea43302440c8aaecf
- 出典データセット
- uspto-grants-1993_06
- 特許番号
- US05216134
反応ノート
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