Cholesterol → Cholesteryl Oleate

HRID 1587650

反応式

HRID 1587650 の反応式
[CH3:1][CH:2]([CH2:4][CH2:5][CH2:6][C@H:7]([C@@H:9]1[C@:27]2([CH3:28])[C@H:12]([C@H:13]3[C@H:24]([CH2:25][CH2:26]2)[C@:22]2([CH3:23])[C:16]([CH2:17][C@H:18]([CH2:20][CH2:21]2)[OH:19])=[CH:15][CH2:14]3)[CH2:11][CH2:10]1)[CH3:8])[CH3:3].[C:29](O)(=[O:47])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]/[CH:37]=[CH:38]\[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46].C(CC(C)(C)C)(C)C>CCOCC>[CH3:46][CH2:45][CH2:44][CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]/[CH:38]=[CH:37]\[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][C:29]([O:19][C@@H:18]1[CH2:17][C:16]2[C@@:22]([CH3:23])([C@@H:24]3[C@@H:13]([CH2:14][CH:15]=2)[C@@H:12]2[CH2:11][CH2:10][C@H:9]([C@@H:7]([CH2:6][CH2:5][CH2:4][CH:2]([CH3:1])[CH3:3])[CH3:8])[C@@:27]2([CH3:28])[CH2:26][CH2:25]3)[CH2:21][CH2:20]1)=[O:47]

参加物

5

反応物 3

HCID 5997CholesterolHCID 109072,2,4-TrimethylpentaneHCID 445639Oleic Acid

生成物 1

HCID 5283632Cholesteryl Oleate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 10 g of cholesterol, 22 g of oleic acid, 50 ml of isooctane and 200 ml (50,000 U) of an aqueous solution of lipase MY was stirred at 200 rpm for 18 hours. Thereafter, ether was added and the mixture was washed with aqueous sodium bicarbonate to remove the aqueous layer. After several repetitions of this procedure, the ether layer was dried on anhydrous sodium sulfate. The ether was then distilled off to give cholesteryl oleate, which was a white semi-transparent crude product, in 96.3% purity and in a yield of 16.0 g (95.0%).

後処理

  1. washthe mixture was washed with aqueous sodium bicarbonate
  2. customto remove the aqueous layer
  3. dry with materialAfter several repetitions of this procedure, the ether layer was dried on anhydrous sodium sulfate
  4. distillationThe ether was then distilled off

出典と根拠

ORDレコード
ord-b156ad3af2fa44838c586936ad0a1aa4
出典データセット
uspto-grants-1993_06
特許番号
US05219733

関連ノート

読み込み中…