Dimethylformamide → 4-Formylbenzoic acid

HRID 1588919ノート

反応式

HRID 1588919 の反応式
S(Cl)(Cl)=[O:2].CN(C)[CH:7]=[O:8].[CH:10]1(NC2CCCC2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.C1[CH2:26][O:25]CC1>C1C=CC=CC=1>[C:26]([C:10]1[CH:11]=[CH:12][C:13]([CH:7]=[O:8])=[CH:14][CH:15]=1)([OH:25])=[O:2]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 24386Thionyl ChlorideHCID 219797n-Cyclopentylcyclohexanamine

生成物 1

HCID 120884-Formylbenzoic acid

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

The acid chloride of 4-carboxybenzaldehyde (7.0 g, 46.5 mmol) was prepared in the same manner as in Example 29 using thionyl chloride (3.5 mL) and dimethylformamide (0.34 mL) in benzene (250 mL). The amide was prepared from the acid chloride in the same manner and using the same workup procedure as in Example 29 using N-cyclohexyl-N-cyclopentyl amine (15.6 g, 93.1 mmol) in THF (150 mL) at 0° C. The crude product was suitable for use without further purification.

後処理

  1. customat 0° C
  2. customThe crude product was suitable for use without further purification

出典と根拠

ORDレコード
ord-a872729bfc2f4169ba1c28cdba5a239d
出典データセット
uspto-grants-1993_06
特許番号
US05223539

反応ノート

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