Amlodipine → HCID 14528697、化合物

反応式

[NH2:1][CH2:2][CH2:3][O:4][CH2:5][C:6]1[NH:7][C:8]([CH3:28])=[C:9]([C:24]([O:26][CH3:27])=[O:25])[CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[Cl:23])[C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].[C:29](N1C=CN=C1)([N:31]1[CH:35]=[CH:34][N:33]=[CH:32]1)=[O:30].CN1CCOCC1>O1CCCC1>[Cl:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH:10]1[C:9]([C:24]([O:26][CH3:27])=[O:25])=[C:8]([CH3:28])[NH:7][C:6]([CH2:5][O:4][CH2:3][CH2:2][NH:1][C:29]([N:31]2[CH:35]=[CH:34][N:33]=[CH:32]2)=[O:30])=[C:11]1[C:12]([O:14][CH2:15][CH3:16])=[O:13]

参加物

実験手順

A solution of 2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (20.4 g), carbonyldiimidazole (8.9 g) and N-methylmorpholine (20 ml) in tetrahydrofuran (500 ml) was stirred at room temperature for 2 hours and then evaporated. The residue was partitioned between ethyl acetate and water and the organic layer washed with water, dried (Na2SO4), and evaporated. The residual solid was washed with diethyl ether and dried to give the title compound (16.6 g), m.p. 149°-151° C. Found: C,57.35; H,5.54; N,11.22. C24H27ClN4O6 requires: C,57.54; H,5.43; N,11.18%.