Octanoyl chloride → HCID 20246378、化合物
反応式
[NH2:1][C:2]1[N:7]=[C:6]2[N:8]=[CH:9][CH:10]=[C:5]2[C:4](=[O:11])[N:3]=1.[C:12](Cl)(=[O:20])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>N1C=CC=CC=1>[C:12]([NH:1][C:2]1[N:7]=[C:6]2[N:8]=[CH:9][CH:10]=[C:5]2[C:4](=[O:11])[N:3]=1)(=[O:20])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]参加物
4
反応条件
- 温度
- 85 °C
実験手順
2-Aminopyrrolo(2,3-d)pyrimidin-4-one (6.0 g) is suspendeed in pyridine (80 ml) and, with stirring on an ice bath, n-octanoyl chloride (22.8 g) is added. The reaction mixture is warmed at 85° C. for 30 minutes and the solvent is distilled off under reduced pressure. Dilute hydrochloric acid is added to the residue and the mixture is extracted with chloroform. The extracts are combined and concentrated to dryness. The residue is dissolved in 8% (W/V) alcoholic ammonia (50 ml) and the solution is allowed to stand at room temperature to give the above-identified compound (8.9 g) as crystals.