2-Chloronaphthalene → 2-(2-Naphthyl)-6-hydroxybenzoxazole

HRID 1591040

反応式

HRID 1591040 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1Cl.Cl.[NH2:13][C:14]1[CH:20]=[CH:19][C:17]([OH:18])=[CH:16][C:15]=1[OH:21].[OH-].[Na+].[CH2:24]1COCC1>CO.O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:24]1[O:21][C:15]2[CH:16]=[C:17]([OH:18])[CH:19]=[CH:20][C:14]=2[N:13]=1

参加物

7

反応物 4

HCID 70562-ChloronaphthaleneHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 134088224-Aminobenzene-1,3-diol hydrochloride

生成物 1

HCID 197660272-(2-Naphthyl)-6-hydroxybenzoxazole収率 47.5%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

20 g (104.9 mmol) of 2-naphthyl chloride and 2.5 g (15.5 mmol) of 4-aminoresorcinol hydrochloride were introduced into a three-necked flask provided with a thermometer and a cooling condenser, and the mixture was heated at 135° to 205° C. for 1 hour, then excessive acid chloride was removed by distillation. To the residue, 8.3 g (207.5 mmol) of NaOH, 60 ml of THF, 60 ml of water and 30 ml of methanol were added, and the mixture was stirred at room temperature for about 2 hours. The reaction solution was extracted with ethyl acetate, the extract was washed with saturated sodium chloride water solution, and ethyl acetate was distilled off. Recrystallizing the residue with water/methanol/THF and drying the crystal, there was obtained 1.92 mg (7.36 mmol) of 2-(2-naphthyl)-6-hydroxybenzoxazole. The yield was 47.5%.

後処理

  1. customprovided with a thermometer and a cooling condenser
  2. temperaturethe mixture was heated at 135° to 205° C. for 1 hour
  3. customexcessive acid chloride was removed by distillation
  4. extractionThe reaction solution was extracted with ethyl acetate
  5. washthe extract was washed with saturated sodium chloride water solution, and ethyl acetate
  6. distillationwas distilled off
  7. customRecrystallizing the residue with water/methanol/THF
  8. customdrying the crystal

出典と根拠

ORDレコード
ord-7d59f3617b824bcdb9d430a7dd9c0ccb
出典データセット
uspto-grants-1993_04
特許番号
US05206149

関連ノート

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