Hydrochloric Acid → Methyl phenethylcarbamate
反応式
[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(N(CC)CC)C.Cl[C:18]([O:20][CH3:21])=[O:19].Cl>C1COCC1.C(OCC)C>[CH3:21][O:20][C:18]([NH:9][CH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)=[O:19]参加物
7
実験手順
To a stirred solution of phenethylamine (75.2 mL, 0.6 mol) and triethylamine (83 mL, 0.6 mol) in THF (500 mL) was added slowly methyl chloroformate 46.2 mL, 0.6 mol) dissolved in THF (50 mL). After the reaction was stirred for an additional 1 h at room temperature, diethyl ether (2 L) and 1N HCl (800 mL) were added. The organic layer was washed with water, dried (MgSO4), filtered, and the filtrate was concentrated in vacuo to give a clear oil of pure title compound (102 g, 95%).
後処理
- washThe organic layer was washed with water
- dry with materialdried (MgSO4)
- filtrationfiltered
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-bbd17ea5df144cd0a50c633bd92af129
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05726159
反応ノート
読み込み中…