Ammonium formate → HCID 10934154、化合物

HRID 1593477ノート

反応式

HRID 1593477 の反応式
C1([C@@H]([NH:9][C@H:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12][C@@H:11]2[C:23]([O:25][CH3:26])=[O:24])C)C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:9][C@H:10]1[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:17])[CH2:12][C@@H:11]1[C:23]([O:25][CH3:26])=[O:24]

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 58745501HCID 58745501、化合物

生成物 1

HCID 10934154HCID 10934154、化合物収率 96%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 260A (1.10 g, 3.03 mmol) in MeOH (31 mL) at room temperature was treated with ammonium formate (1.51 g, 24.3 mmol) and 10% Pd/C (110 mg). The reaction mixture was heated to reflux for 14 hours then cooled to room temperature. The solid material was removed by filtration and washed with MeOH. The filtrate was concentrated in vacuo to give 0.75 g (yield: 96%) of Compound 260B as an oil.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 14 hours
  3. customThe solid material was removed by filtration
  4. washwashed with MeOH
  5. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-89d2a62411554ddba61dab644476d38b
出典データセット
uspto-grants-2007_11
特許番号
US07297695B2

反応ノート

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