Sodium Hydroxide → (2-Fluorobiphenyl-4-yl)methanol

HRID 1594138ノート

反応式

HRID 1594138 の反応式
[F:1][C:2]1[CH:7]=[C:6]([CH:8]=[O:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[BH4-].[Na+].[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 27590832-Fluorobiphenyl-4-carboxaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 46314883(2-Fluorobiphenyl-4-yl)methanol収率 80%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Fluoro-biphenyl-4-carbaldehyde (1 gm, 5 mmole), NaBH4 were dissolved in ethanol stirred for 2 hrs, NaOH 10% was added, ethanol was evaporated, the reaction mixture was extracted with ethyl acetate, the ethyl acetate extract was dried with Na2SO4 and evaporated to produce white solid (0.8 gm, 80%). H1-NMR INOVA-500 (CDCl3) δ 2.266 (s, 1H), 4.683 (s, 2H), 7.142-7.168 (m, 2H), 7.339-7.442 (m, 4H), 7.519-7.535 (m, 2H).

後処理

  1. customethanol was evaporated
  2. extractionthe reaction mixture was extracted with ethyl acetate
  3. extractionthe ethyl acetate extract
  4. dry with materialwas dried with Na2SO4
  5. customevaporated

出典と根拠

ORDレコード
ord-225f74ce1462401e8f99a679b3109c8c
出典データセット
uspto-grants-2007_11
特許番号
US07300931B2

反応ノート

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