m-Chloroperbenzoic acid → 3-Methylsulfonyl-5-(cyclohexyl)methyl-1,2,4-thiadiazole

HRID 1594419ノート

反応式

HRID 1594419 の反応式
CS[C:3]1[N:7]=[C:6]([CH2:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[S:5][N:4]=1.Cl[C:16]1C=C(C=CC=1)C(OO)=O.[S:26]([O-:29])(O)=[O:27].[Na+]>C(Cl)(Cl)Cl>[CH3:16][S:26]([C:3]1[N:7]=[C:6]([CH2:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[S:5][N:4]=1)(=[O:29])=[O:27]

参加物

5

反応物 3

HCID 70297m-Chloroperbenzoic acidHCID 23665763Sodium BisulfiteHCID 586104393-Methylthio-5-(cyclohexyl)methyl-1,2,4-thiadiazole

生成物 1

HCID 690245423-Methylsulfonyl-5-(cyclohexyl)methyl-1,2,4-thiadiazole

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

1.2 g of 3-methylthio-5-(cyclohexyl)methyl-1,2,4-thiadiazole was dissolved in 20 ml of chloroform, 2.78 g of 3-chloroperoxybenzoic acid (content>65%) was added thereto, and the reaction mixture was stirred for 1 hour under ice-cooling and for 16 hours at room temperature. Then, the reaction mixture was added to saturated sodium hydrogensulfite aqueous solution, and separated. The organic layer was washed with sodium hydrogencarbonate aqueous solution, dried over anhydrous sodium sulfate, concentrated to give 1.4 g of 3-methylsulfonyl-5-(cyclohexyl)methyl-1,2,4-thiadiazole.

後処理

  1. customseparated
  2. washThe organic layer was washed with sodium hydrogencarbonate aqueous solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-59a78a59556248c28fc5abf310fb4ea5
出典データセット
uspto-grants-2007_11
特許番号
US07301032B2

反応ノート

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