Methyl iodide → HCID 178504149、化合物

HRID 1594980

反応式

HRID 1594980 の反応式
[NH2:1][C:2]([NH:4][C:5]([NH2:7])=[S:6])=[S:3].[I:8][CH3:9]>C1COCC1.C1(C)C=CC=CC=1>[IH:8].[CH3:9][SH:3]=[C:2]([NH:4][C:5]([NH2:7])=[S:6])[NH2:1]

参加物

5

反応物 2

HCID 6328Methyl iodideHCID 2758725Dithiobiuret

生成物 1

HCID 178504149HCID 178504149、化合物収率 85%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirring solution of dithiobiuret (5.0 g, 37 mmol) in THF (75 mL) was added iodomethane (13.1 g, 92.5 mmol, 5.76 ml). After stirring at room temperature for 22 h, the solution was diluted with 150 mL of toluene and allowed to stand at 0° C. for 3 h. The crystals were collected by filtration and washed with cold 2:1 toluene/THF, then dried in vacuo to give the title compound as a white solid (8.7 g, 85%). MS (ESI): 149.9 (M+H)+.

後処理

  1. waitto stand at 0° C. for 3 h
  2. filtrationThe crystals were collected by filtration
  3. washwashed with cold 2:1 toluene/THF
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-7d8af54153e149f8b0ece54b8604e925
出典データセット
uspto-grants-2001_09
特許番号
US06284777B1

関連ノート

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