Dimethylamine, hydrochloride → N-(4-dimethylaminomethylphenylmethyl)acetamide

HRID 1595377ノート

反応式

HRID 1595377 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1.Cl.[CH3:15][NH:16][CH3:17].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:15][N:16]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1)[CH3:17]

参加物

5

反応物 3

HCID 10473Dimethylamine, hydrochlorideHCID 11430Potassium CarbonateHCID 15550682N-((4-(chloromethyl)phenyl)methyl)acetamide

生成物 1

HCID 21703715N-(4-dimethylaminomethylphenylmethyl)acetamide収率 136.1%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

N-(4-Chloromethylphenylmethyl)acetamide (20.0 g) and dimethylamine hydrochloride (9.1 g) were dissolved in acetonitrile (190 ml), and potassium carbonate (28 g) was added. The mixture was refluxed under heating overnight. An insoluble solid was filtered off and the solvent was evaporated to give the objective N-(4-dimethylaminomethylphenylmethyl)acetamide (28.4 g) as an oil.

後処理

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating overnight
  3. filtrationAn insoluble solid was filtered off
  4. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-003b84edd6804181a283ab5e3d577154
出典データセット
uspto-grants-2001_09
特許番号
US06288061B1

反応ノート

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