1-Bromonaphthalene-2-carbaldehyde → (1-Bromonaphthalen-2-yl)methanol
反応式
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH:12]=[O:13].[BH4-].[Na+]>CO>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH2:12][OH:13]参加物
4
実験手順
A solution of 1-bromo-2-naphthaldehyde (2.12 g, 8.91 mmol) in MeOH under N2 at 0° C. was treated with NaBH4 (0.51 g, 13.4 mmol), stirred for 15 minutes, quenched with acetone, and concentrated. Purification on silica gel with 5% ethyl acetate/CH2Cl2 provided 1.95 g (92%) of the desired compound as a white solid.
後処理
- customquenched with acetone
- concentrationconcentrated
- customPurification on silica gel with 5% ethyl acetate/CH2Cl2
出典と根拠
- ORDレコード
- ord-6e3aac090eda42cfb50f990f50991962
- 出典データセット
- uspto-grants-2001_09
- 特許番号
- US06288261B1
反応ノート
読み込み中…