1-Chloro-4-morpholin-4-yl-2-naphthol → 4-Morpholino-2-naphthol

HRID 1596668

反応式

HRID 1596668 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:4][C:3]=1[OH:18]>[OH-].[Na+].C(O)C.[Pd]>[O:15]1[CH2:14][CH2:13][N:12]([C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH:2]=[C:3]([OH:18])[CH:4]=2)[CH2:17][CH2:16]1

参加物

5

反応物 1

HCID 6096921-Chloro-4-morpholin-4-yl-2-naphthol

生成物 1

HCID 109880424-Morpholino-2-naphthol収率 77.8%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

in a 0.3 l steel autoclave, 10.5 g of 1-chloro-4-morpholino-2-naphthol in 150 ml of sodium hydroxide (2N) and 30 ml of ethanol are maintained under a pressure of 3 bar and at 35° C. in the presence of 3 g of palladium on charcoal (5%) for 7 hours. The solution is then filtered to remove the catalyst. The aqueous phase is then acidified with acetic acid and then filtered. The precipitate is washed with water and then dried. 7.1 g of 4-morpholino-2-naphthol are thus obtained.

後処理

  1. filtrationThe solution is then filtered
  2. customto remove the catalyst
  3. filtrationfiltered
  4. washThe precipitate is washed with water
  5. customdried

出典と根拠

ORDレコード
ord-9097480114864321971c9a53acc09a4f
出典データセット
uspto-grants-2001_09
特許番号
US06291561B1

関連ノート

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