Methyl iodide → 5-Chloro-2-hydroxymethyl-3-methylimidazo[5,4-b]pyridine

HRID 1599282ノート

反応式

HRID 1599282 の反応式
[Cl:1][C:2]1[N:7]=[C:6]2[NH:8][C:9]([CH2:11][OH:12])=[N:10][C:5]2=[CH:4][CH:3]=1.[H-].[Na+].[CH3:15]I>CN(C)C=O>[Cl:1][C:2]1[N:7]=[C:6]2[N:8]([CH3:15])[C:9]([CH2:11][OH:12])=[N:10][C:5]2=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 178519929HCID 178519929、化合物

生成物 1

HCID 106555445-Chloro-2-hydroxymethyl-3-methylimidazo[5,4-b]pyridine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A procedure similar to that described in Preparation 15 was repeated, except that 3.00 g of 5-chloro-2-hydroxymethyl-3H-imidazo[5,4-b]pyridine (prepared as described in Preparation 43), 0.71 g of sodium hydride (as a 55% by weight dispersion in mineral oil), 1.1 ml of methyl iodide and 70 ml of dimethylformamide were used, to give the title compound as a crude product. This crude product was purified by column chromatography through silica gel, using a gradient elution method, with mixtures of ethyl acetate and methanol in ratios ranging from 1:0 to 10:1 by volume as the eluent, to give 1.60 g of the title compound, melting at 204°-210° C.

後処理

  1. customA procedure similar to that described in Preparation 15

出典と根拠

ORDレコード
ord-780db4464dad4014a74a298894cb4da5
出典データセット
uspto-grants-1998_04
特許番号
US05739345

反応ノート

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