1-Hexanol → 3-(3-Hexyloxy-1,2,5-thiadiazol-4-yl)-6-methylpyridine

HRID 1600322ノート

反応式

HRID 1600322 の反応式
[H-].[Na+].[CH2:3]([OH:9])[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Cl[C:11]1[C:15]([C:16]2[CH:17]=[N:18][C:19]([CH3:22])=[CH:20][CH:21]=2)=[N:14][S:13][N:12]=1>C1COCC1>[CH2:3]([O:9][C:11]1[C:15]([C:16]2[CH:17]=[N:18][C:19]([CH3:22])=[CH:20][CH:21]=2)=[N:14][S:13][N:12]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

5

反応物 3

HCID 81031-HexanolHCID 24758Sodium hydrideHCID 190752683-(3-Chloro-1,2,5-thiadiazol-4-yl)-6-methylpyridine

生成物 1

HCID 190755123-(3-Hexyloxy-1,2,5-thiadiazol-4-yl)-6-methylpyridine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Sodium hydride (0.72 g, 15 mmol) was dissolved in dry THF (20 ml) and 1-hexanol (1.53 g, 15 mmol) and a solution of 3-(3-chloro-1,2,5-thiadiazol-4-yl)-6-methylpyridine (1.06 g, 5 mmol) in dry THF (15 ml) was added. The reaction mixture was stirred for 2 h. Afteraddition of water the mixture was extracted with ether, and the ether phasewas dried and evaporated. The residue consisted of the crude title compound, which was used without further purification.

後処理

  1. extractionAfteraddition of water the mixture was extracted with ether
  2. dry with materialthe ether phasewas dried
  3. customevaporated
  4. customwas used without further purification

出典と根拠

ORDレコード
ord-d4c417f90a8e4199b9e81f94640c9094
出典データセット
uspto-grants-1998_04
特許番号
US05744489

反応ノート

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