Potassium Hydroxide → 2-[(4-Fluorophenethyl)oxy]ethylamine
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][O:10][CH2:11][CH2:12][NH:13]C(=O)OC)=[CH:4][CH:3]=1.[OH-].[K+].O.NN>C(O)CO.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][O:10][CH2:11][CH2:12][NH2:13])=[CH:6][CH:7]=1参加物
6
実験手順
The product of step d) (8.0 g) was dissolved in ethylene glycol and to this was added potassium hydroxide (48 g) and hydrazine hydrate (8.3 ml). The stirred mixture was heated to 140° for 4 hours then allowed to cool to room temperature overnight. The mixture was then diluted with water and extracted with diethyl ether (×3). The combined organic extracts were washed with brine, dried (MgOS4) and filtered. The volatiles were removed in vacuo to give the subtitle compound (5.36 g).
後処理
- temperatureThe stirred mixture was heated to 140° for 4 hours
- extractionextracted with diethyl ether (×3)
- washThe combined organic extracts were washed with brine
- dry with materialdried (MgOS4)
- filtrationfiltered
- customThe volatiles were removed in vacuo
出典と根拠
- ORDレコード
- ord-d044ce34d31140049896bfc688fc6551
- 出典データセット
- uspto-grants-1999_11
- 特許番号
- US05977384
反応ノート
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