1-Azabicyclo[2.2.2]oct-3-yl methanesulfonate → HCID 15663665、化合物

HRID 1602333

反応式

HRID 1602333 の反応式
CS(O[CH:6]1[CH:11]2[CH2:12][CH2:13][N:8]([CH2:9][CH2:10]2)[CH2:7]1)(=O)=O.[Na].[NH2:15][C:16]1[NH:20][N:19]=[N:18][N:17]=1>CN(C=O)C>[NH2:15][C:16]1[N:17]=[N:18][N:19]([CH:6]2[CH:11]3[CH2:12][CH2:13][N:8]([CH2:9][CH2:10]3)[CH2:7]2)[N:20]=1

参加物

5

反応物 3

HCID 4164941-Azabicyclo[2.2.2]oct-3-yl methanesulfonateHCID 5360545SodiumHCID 178509299HCID 178509299、化合物

生成物 1

HCID 15663665HCID 15663665、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

3-Methanesulphonyloxy-1-azabicylo[2.2.2]octane (D8) (2.0 g, 9.7 mmol) and the sodium salt of 5-aminotetrazole (D15) (2.5 g, 2.0 eq) were dissolved in dry DMF (50 ml) and the reaction carried out as for Example 10. The product (E11) isolated from column chromatography was a white crystalline solid (124 mg, 6.6%), which was recrystallised from ether, m.p. 132-134° C.

後処理

  1. customThe product (E11) isolated from column chromatography
  2. customwas recrystallised from ether, m.p. 132-134° C.

出典と根拠

ORDレコード
ord-de9bc4b61d6341baa4ed99bafa2397b6
出典データセット
uspto-grants-1999_11
特許番号
US05981545

関連ノート

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