Sodium Hydroxide → 1-Quinolin-6-yl-ethanone oxime

HRID 16024

反応式

HRID 16024 の反応式
Cl.[NH2:2][OH:3].[OH-].[Na+].[N:6]1[C:15]2[C:10](=[CH:11][C:12]([C:16](=O)[CH3:17])=[CH:13][CH:14]=2)[CH:9]=[CH:8][CH:7]=1>CCO>[N:6]1[C:15]2[C:10](=[CH:11][C:12]([C:16](=[N:2][OH:3])[CH3:17])=[CH:13][CH:14]=2)[CH:9]=[CH:8][CH:7]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 2585591-(Quinolin-6-yl)ethan-1-oneHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 722593651-Quinolin-6-yl-ethanone oxime収率 99%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒3 回

実験手順

To a suspension of hydroxylamine hydrochloride in EtOH (150 mL) was added a suspension of NaOH (2.4 g, 59.7 mmol) in EtOH (25 mL). The reaction mixture was stirred at ambient temperature for 15 minutes. The precipitated sodium hydrochloride was filtered off. A solution of 1-quinolin-6-yl-ethanone (9.3 g, 54.25 mmol) in EtOH (150 mL) was added. The reaction solution was stirred for 16 hours at ambient temperature. EtOH was removed in vacuum to give 1-quinolin-6-yl-ethanone oxime (10.1 g, >99% yield).

後処理

  1. additionwas added
  2. filtrationThe precipitated sodium hydrochloride was filtered off
  3. stirringThe reaction solution was stirred for 16 hours at ambient temperature
  4. customEtOH was removed in vacuum

出典と根拠

ORDレコード
ord-816d608857b34abfbff324ae548cd0f4
出典データセット
uspto-grants-2010_06
特許番号
US07732604B2

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