Tetrahydrofuran → 3-(4,5,6,7-Tetrahydrobenzothiazol-2-ylmethoxy)benzoic acid

HRID 1602492ノート

反応式

HRID 1602492 の反応式
[S:1]1[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:4]=2[N:3]=[C:2]1[CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:19]=[CH:20][CH:21]=1)[C:15]([O:17]C)=[O:16].O1CCCC1.[OH-].[Na+]>CO>[S:1]1[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:4]=2[N:3]=[C:2]1[CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:19]=[CH:20][CH:21]=1)[C:15]([OH:17])=[O:16]

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 19611521Methyl 3-(4,5,6,7-tetrahydrobenzothiazol-2-ylmethoxy)benzoate

生成物 1

HCID 196115783-(4,5,6,7-Tetrahydrobenzothiazol-2-ylmethoxy)benzoic acid収率 75%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of methyl 3-(4,5,6,7-tetrahydrobenzothiazol-2-ylmethoxy)benzoate (361 mg, 1.2 mmol), tetrahydrofuran (2 ml), methanol (2 ml) and 1 N sodium hydroxide (2 ml) was stirred at room temperature for 12 hours and then concentrated under reduced pressure. The resulting residue was dissolved in water and the solution was adjusted to pH 3 by adding 10% citric acid aqueous solution. Thereafter, the solid substance formed was collected by filtration, washed with water, and then dried under reduced pressure to give 3-(4,5,6,7-tetrahydrobenzothiazol-2-ylmethoxy)benzoic acid (257 mg, 0.89 mmol, 75%).

後処理

  1. concentrationconcentrated under reduced pressure
  2. dissolutionThe resulting residue was dissolved in water
  3. additionby adding 10% citric acid aqueous solution
  4. customThereafter, the solid substance formed
  5. filtrationwas collected by filtration
  6. washwashed with water
  7. customdried under reduced pressure

出典と根拠

ORDレコード
ord-a7e677c24d794a738ca9e02d5e8b4ac4
出典データセット
uspto-grants-1999_11
特許番号
US05981559

反応ノート

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