Hydrochloric Acid → 4-(3-Carboxypropyl)Amino-6,7,8-Trimethoxyquinazoline

HRID 1603525ノート

反応式

HRID 1603525 の反応式
[OH-].[Na+].C([O:5][C:6]([CH2:8][CH2:9][CH2:10][NH:11][C:12]1[C:21]2[C:16](=[C:17]([O:26][CH3:27])[C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1)=[O:7])C.C(O)C.Cl>O1CCCC1>[C:6]([CH2:8][CH2:9][CH2:10][NH:11][C:12]1[C:21]2[C:16](=[C:17]([O:26][CH3:27])[C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1)([OH:7])=[O:5]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 97984504-(3-Ethoxycarbonylpropyl)Amino-6,7,8-Trimethoxyquinazoline

生成物 1

HCID 98619074-(3-Carboxypropyl)Amino-6,7,8-Trimethoxyquinazoline収率 744%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

5 ml of a 1N aqueous solution of sodium hydroxide is added to a solution of 0.52 g (1.5 mmol) of the 4-(3-ethoxycarbonylpropyl)amino-6,7,8-trimethoxyquinazoline obtained in Example 1 in tetrahydrofuran (5 ml)/ethanol (5 ml), followed by stirring at room temperature one whole day and night. The reaction liquid is neutralized with 5 ml of 1N hydrochloric acid, and then concentrated under reduced pressure. The crystals thus precipitated are recovered by filtration, washed with water, and dried with air. Thus, 0.36 g (yield 744%) of a pale-yellow crystal is obtained.

後処理

  1. customThe reaction liquid
  2. concentrationconcentrated under reduced pressure
  3. customThe crystals thus precipitated
  4. filtrationare recovered by filtration
  5. washwashed with water
  6. customdried with air

出典と根拠

ORDレコード
ord-0a80c348d3af4ddcb017380d41b1652c
出典データセット
uspto-grants-1999_11
特許番号
US05990117

反応ノート

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