Chlorotrimethylsilane → N,N-Diethyl-2-(trimethylsilyl)-1-naphthalenecarboxamide

HRID 1604230

反応式

HRID 1604230 の反応式
[CH2:1]([N:3]([CH2:16][CH3:17])[C:4]([C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][CH:7]=1)=[O:5])[CH3:2].[CH3:18][Si:19](Cl)([CH3:21])[CH3:20]>>[CH2:16]([N:3]([CH2:1][CH3:2])[C:4]([C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][C:7]=1[Si:19]([CH3:21])([CH3:20])[CH3:18])=[O:5])[CH3:17]

参加物

3

反応物 2

HCID 6397ChlorotrimethylsilaneHCID 229388N,N-Diethyl-1-naphthamide

生成物 1

HCID 15828028N,N-Diethyl-2-(trimethylsilyl)-1-naphthalenecarboxamide収率 71%

実験手順

N,N-Diethyl-1-naphthalenecarboxamide was reacted with 2 eq TMSCl according to General Method A. The resulting reaction mixture was worked up in the usual manner, then purified by chromatography with 20% ethyl acetate/80% hexanes to afford 2.1 g of the desired compound as a clear oil, a 71% yield.

後処理

  1. customThe resulting reaction mixture
  2. custompurified by chromatography with 20% ethyl acetate/80% hexanes

出典と根拠

ORDレコード
ord-3e590ffdfe7c427881eabbc3eee42cca
出典データセット
uspto-grants-1999_11
特許番号
US05994270

関連ノート

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