Chloroform → 2-(4-Acetylphenoxy)-2-methylpropionic acid

HRID 1605118

反応式

HRID 1605118 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[OH-:11].[Na+].C(Cl)(Cl)Cl>CC(C)=O>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([O:1][C:5]([CH3:6])([CH3:4])[C:8]([OH:10])=[O:11])=[CH:3][CH:4]=1)(=[O:10])[CH3:9]

参加物

5

反応物 3

HCID 6212ChloroformHCID 74694'-HydroxyacetophenoneHCID 14798Sodium Hydroxide

生成物 1

HCID 1041062-(4-Acetylphenoxy)-2-methylpropionic acid

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

2-(p-Acetylphenoxy)-2-methylpropionic acid was prepared from 545 g. of p-hydroxyacetophenone, 960 g. of sodium hydroxide and 715 g. of chloroform in 11 liters of acetone according to the procedure described above in Example 1, part (d). The product was recrystallized from carbon tetrachloride and from isopropyl acetate to give 2-(p-acetylphenoxy)-2-methylpropionic acid as a pale cream solid, m.p. 108°-110°C.

後処理

  1. custom2-(p-Acetylphenoxy)-2-methylpropionic acid was prepared from 545 g
  2. customThe product was recrystallized from carbon tetrachloride and from isopropyl acetate

出典と根拠

ORDレコード
ord-43972321ca904c3ca0b13546863795ca
出典データセット
uspto-grants-1976_04
特許番号
US03948973

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