Hydrochloric Acid → 3-(Methylthio)-5-(trifluoromethyl)benzoic acid
反応式
[SH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5]([OH:7])=[O:6].[OH-].[Na+].[CH3:17]I.Cl>C(O)C>[CH3:17][S:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:10]=1)[C:5]([OH:7])=[O:6]参加物
6
実験手順
To a solution of 10 g. (0.045 mole) of 3-mercapto-5-trifluoromethylbenzoic acid, and 100 ml. of 1N sodium hydroxide in 100 ml. of ethanol is added 3.8 ml. (0.06 mole) of methyl iodide. After the reaction has stirred at room temperature for one hour, it is acidified with 12N hydrochloric acid, and the precipitate of the final product is filtered and dried,8.6 g., m.p. 135°-140° C. A sample is sublimed at 175° C. and 0.03 mm pressure, m.p. 151°-152.5° C.
後処理
- filtrationthe precipitate of the final product is filtered
- customdried
- customis sublimed at 175° C.
出典と根拠
- ORDレコード
- ord-6ccdc6fdae374e30a10ed670f7e67ae9
- 出典データセット
- uspto-grants-1976_04
- 特許番号
- US03953595
反応ノート
読み込み中…