Water → 4-Methylthio-3-(trifluoromethyl)phenylboronic acid pinacol ester

HRID 16069

反応式

HRID 16069 の反応式
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([B:9]([OH:11])[OH:10])=[CH:5][C:4]=1[C:12]([F:15])([F:14])[F:13].O[C:17]([C:20](O)([CH3:22])[CH3:21])([CH3:19])[CH3:18].C(OCC)C.O>O1CCOCC1>[CH3:18][C:17]1([CH3:19])[C:20]([CH3:22])([CH3:21])[O:11][B:9]([C:6]2[CH:7]=[CH:8][C:3]([S:2][CH3:1])=[C:4]([C:12]([F:15])([F:13])[F:14])[CH:5]=2)[O:10]1

参加物

6

反応物 4

HCID 962WaterHCID 3283Diethyl EtherHCID 6425PinacolHCID 748911694-Methylthio-3-(trifluoromethyl)phenylboronic acid

生成物 1

HCID 672773014-Methylthio-3-(trifluoromethyl)phenylboronic acid pinacol ester

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

The product of step b) (0.25 g) was heated in dioxan (2 ml) with pinacol (2 equiv) for 3 h. The solution was treated with diethyl ether and water. The organic layer was separated, washed with brine, dried (Na2SO4) and concentrated in vacuo. Yield 85 mg.

後処理

  1. customThe organic layer was separated
  2. washwashed with brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-4377e4d71b804528910e589e09a43d88
出典データセット
uspto-grants-2010_06
特許番号
US07737135B2

関連ノート

読み込み中…