Water → 2-Methyl-N-(2-methylbutan-2-yl)prop-2-enamide

HRID 1608004ノート

反応式

HRID 1608004 の反応式
[CH3:1][C:2](=[CH:4][CH3:5])[CH3:3].[C:6](#[N:10])[C:7]([CH3:9])=[CH2:8].S(=O)(=O)(O)[OH:12].O>C(O)(=O)C>[CH3:1][C:2]([NH:10][C:6](=[O:12])[C:7]([CH3:9])=[CH2:8])([CH2:4][CH3:5])[CH3:3]

参加物

6

反応物 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 105532-Methyl-2-buteneHCID 31368Methacrylonitrile

生成物 1

HCID 146180182-Methyl-N-(2-methylbutan-2-yl)prop-2-enamide収率 65.2%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2-Methyl-2-butene (7.0 g) was added to a stirred mixture of methacrylonitrile (6.7 g) in acetic acid (50 ml) and concentrated sulfuric acid (10 g) at 10° to 20° C. The mixture was allowed to stand overnight at room temperature, and then poured into 200 g of water and extracted with methylene chloride (2×100 ml). The methylene chloride solution was dried over sodium sulfate, the solid filtered off and the methylene chloride evaporated to afford an oily product. Distillation of the product at 10 mm yielded N-(2-methyl-2-butyl)methacrylamide (10.1 g, 65%); bp 84° C.

後処理

  1. extractionextracted with methylene chloride (2×100 ml)
  2. dry with materialThe methylene chloride solution was dried over sodium sulfate
  3. filtrationthe solid filtered off
  4. customthe methylene chloride evaporated
  5. customto afford an oily product
  6. distillationDistillation of the product at 10 mm

出典と根拠

ORDレコード
ord-a79b999e6d39437c8f1e607cf426637d
出典データセット
uspto-grants-1989_09
特許番号
US04868310

反応ノート

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