Water → N-Ethyl-N-phenylnaphthalen-1-amine

HRID 1608714ノート

反応式

HRID 1608714 の反応式
[CH2:1](I)[CH3:2].[C:4]1([NH:10][C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=[CH:13][CH:12]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[OH-].[K+].O>CN1CCCC1=O.[Cu]>[C:4]1([N:10]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=[CH:13][CH:12]=2)[CH2:1][CH3:2])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

7

反応物 4

HCID 962WaterHCID 6340IodoethaneHCID 7013Phenyl-1-naphthylamineHCID 14797Potassium Hydroxide

生成物 1

HCID 20087159N-Ethyl-N-phenylnaphthalen-1-amine収率 98%

試薬・触媒・溶媒 2

HCID 23978Copper触媒HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

A mixture of ethyl iodide (0.1M), 1-phenylaminonaphthalene (0.05M), KOH (0.1M) and copper bronze (1 g) was stirred for 31/2 hours in N-methylpyrrolidone (20 cm3) at 120° C. under an atmosphere of nitrogen. The mixture was cooled, poured into water (2 liters) and extracted with CH2Cl2 (3×300 cm3). The combined extracts were washed with water, dried over MgSO4 and the CH2Cl2 solvent removed in vacuo to give 229 g (98% yield) of 1-(N-phenyl-N-ethylamino)naphthalene as a yellow liquid.

後処理

  1. temperatureThe mixture was cooled
  2. extractionextracted with CH2Cl2 (3×300 cm3)
  3. washThe combined extracts were washed with water
  4. dry with materialdried over MgSO4
  5. customthe CH2Cl2 solvent removed in vacuo

出典と根拠

ORDレコード
ord-f5b9df291c624434ad143b206a8ceb43
出典データセット
uspto-grants-1995_03
特許番号
US05395969

反応ノート

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