Thionyl Chloride → 3-Fluoro-4-(trifluoromethyl)benzyl chloride
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH2:5]O.S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH2:5][Cl:16]参加物
4
実験手順
To absolution of 3-fluoro-4-(trifluoromethyl)benzyl alcohol (10 g, 52 mmol) in chloroform (20 ml) was added thionyl chloride (18.5 ml, 257 mmol) and the mixture was heated under ref lux for 4 hrs. The reaction solution was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to give 3-fluoro-4-(trifluoromethyl)benzyl chloride (9.52 g, 87%).
後処理
- temperaturethe mixture was heated under ref lux for 4 hrs
- concentrationThe reaction solution was concentrated
- customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1)
出典と根拠
- ORDレコード
- ord-bb96693162034c8f9ed3547559716fc4
- 出典データセット
- uspto-grants-2006_01
- 特許番号
- US06982348B2
反応ノート
読み込み中…