Benzyl 4-(pyridin-3-yloxy)benzoate → 4-(Pyridin-3-yloxy)benzoic acid

HRID 1610601

反応式

HRID 1610601 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][C:8]2[CH:23]=[CH:22][C:11]([C:12]([O:14]CC3C=CC=CC=3)=[O:13])=[CH:10][CH:9]=2)[CH:2]=1>C(O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][C:8]2[CH:23]=[CH:22][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=2)[CH:2]=1

参加物

4

反応物 1

HCID 22262109Benzyl 4-(pyridin-3-yloxy)benzoate

生成物 1

HCID 222616674-(Pyridin-3-yloxy)benzoic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a solution of benzyl 4-(pyridin-3-yloxy)benzoate (18.0 g, 5.90 mmol) in ethanol (300 ml) was added 10% palladium/carbon (containing water by 50%, 2.0 g), and the mixture was stirred under a hydrogen stream at 80° C. overnight. The reaction solution was filtered with celite and the filtrate was concentrated. The residue was recrystallized from ethanol-hexane to give the objective substance (11.2 g, 88%).

後処理

  1. filtrationThe reaction solution was filtered with celite
  2. concentrationthe filtrate was concentrated
  3. customThe residue was recrystallized from ethanol-hexane
  4. customto give the objective substance (11.2 g, 88%)

出典と根拠

ORDレコード
ord-1296fd1aaed04fa7848a8fa4f645c4b3
出典データセット
uspto-grants-2006_01
特許番号
US06982348B2

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