m-Chloroperbenzoic acid → Methyl 2-(4-chlorophenyl)oxirane-2-carboxylate
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[CH2:13])[C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.ClC1C=CC=C(C(OO)=[O:22])C=1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([O:22][CH2:13]2)[C:9]([O:11][CH3:12])=[O:10])=[CH:6][CH:7]=1参加物
4
実験手順
To a solution of 19.6 g of methyl 2-(4-chlorophenyl)acrylate in 200 ml of dry chloroform, under an inert atmosphere are added 47.06 g of 55% m-chloroperbenzoic acid and the resulting solution is refluxed for 18 hours. The mixture is then cooled and the solid removed by filtration. Evaporation in vacuo of the filtrate and chromatography of the residue on silica-gel affords methyl 2-(4-chlorophenyl)-2,3-epoxy-propionate as a colourless oil.
後処理
- temperaturethe resulting solution is refluxed for 18 hours
- temperatureThe mixture is then cooled
- customthe solid removed by filtration
- customEvaporation in vacuo of the filtrate and chromatography of the residue on silica-gel
出典と根拠
- ORDレコード
- ord-fda53885c7374412b65bdb45a195c0f0
- 出典データセット
- uspto-grants-1993_03
- 特許番号
- US05190934
反応ノート
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