Methyl chloroformate → 2-Chloro-4-fluoro-methoxycarbonyloxybenzene
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[OH:9].[OH-].[Na+].Cl[C:13]([O:15][CH3:16])=[O:14]>O>[C:13](=[O:14])([O:9][C:3]1[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[Cl:1])[O:15][CH3:16]参加物
5
実験手順
2-Chloro-4-fluorophenol (83.4 g) was added to a solution of sodium hydroxide (27.7 g) in water (450 ml), and methyl chloroformate (69.2 g) was dropwise added thereto at a temperature of below 10° C. Precipitated crystals were collected by filtration and washed with water to give methyl (2-chloro-4-fluorophenyl) carbonate (134.8 g). M.P., 69°-71° C.
後処理
- additionwas dropwise added
- customat a temperature of below 10° C
- customPrecipitated crystals
- filtrationwere collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-2e5f3da1c52c418bbbd53526a7a929c4
- 出典データセット
- uspto-grants-1993_03
- 特許番号
- US05191105
反応ノート
読み込み中…