Sodium hydride → Pentanobenzeneacetic acid

HRID 1613576

反応式

HRID 1613576 の反応式
C([O:3][C:4]([CH2:6][C:7]1[C:12]2[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:11]=2[CH:10]=[CH:9][CH:8]=1)=[O:5])C.C1(=O)C2CCCCCC=2C=CC1.[H-].[Na+]>O1CCCC1>[C:7]1([CH2:6][C:4]([OH:5])=[O:3])[C:12]2[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:11]=2[CH:10]=[CH:9][CH:8]=1

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 21703317Benzocycloheptan-1-oneHCID 537587941-Ethoxycarbonylmethylbenzocycloheptane

生成物 1

HCID 18918733Pentanobenzeneacetic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

(Benzocyclohept-1-en-1-yl)-acetic acid was prepared from 1-ethoxycarbonylmethylbenzocyclohept-1-ene, which was itself prepared from benzocycloheptan-1-one treated with ##STR11## and NaH in tetrahydrofuran, followed by separation of the two exocyclic unsaturated cis- and trans-isomers also formed, the separation being carried out by flash chromatography on silica gel with toluene as eluant.

後処理

  1. customfollowed by separation of the two exocyclic unsaturated cis- and trans-isomers
  2. customalso formed
  3. customthe separation

出典と根拠

ORDレコード
ord-5c94360e4a7e40f3bb5d5ec38d85b435
出典データセット
uspto-grants-1993_03
特許番号
US05194437

関連ノート

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