Sodium Hydroxide → 4-Chloro-5,6,7,8-tetrahydroquinoline
反応式
[N+]([C:4]1[C:13]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[N+:7]([O-])=[CH:6][CH:5]=1)([O-])=O.P(Cl)(Cl)[Cl:16].[OH-].[Na+]>C(Cl)(Cl)Cl>[Cl:16][C:4]1[C:13]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[N:7]=[CH:6][CH:5]=1参加物
5
実験手順
A solution of the crude product of Step 1 (36.5 g, 188 mmol) in chloroform (500 ml) was treated over 30 min with phosphorus trichloride (80 g, 580 mmol) at 0°, heated under reflux for 1 h, cooled to room temperature, and poured onto ice (2 Kg). The mixture was basified with sodium hydroxide and the layers separated. The aqueous phase was extracted with chloroform (500 ml).
後処理
- temperatureheated
- temperatureunder reflux for 1 h
- additionpoured onto ice (2 Kg)
- customthe layers separated
- extractionThe aqueous phase was extracted with chloroform (500 ml)
出典と根拠
- ORDレコード
- ord-267ea5c7d4fd4d5fa78c194b1352f537
- 出典データセット
- uspto-grants-1993_03
- 特許番号
- US05194439
反応ノート
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