Hydrochloric Acid → 1-Propyl-1,3-diazinane-2,4,6-trione

HRID 16145

反応式

HRID 16145 の反応式
[Na].[C:2]([O:10]CC)(=O)[CH2:3][C:4]([O:6]CC)=O.[CH2:13]([NH:16][C:17]([NH2:19])=[O:18])[CH2:14][CH3:15].Cl>O.C(O)C>[CH2:13]([N:16]1[C:2](=[O:10])[CH2:3][C:4](=[O:6])[NH:19][C:17]1=[O:18])[CH2:14][CH3:15]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 7761Diethyl MalonateHCID 12303PropylureaHCID 5360545Sodium2 回

生成物 1

HCID 2855681-Propyl-1,3-diazinane-2,4,6-trione

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Metallic sodium (2.6 g, 113 mmol) is added to ethanol (60 ml). The mixture is stirred until the sodium has completely finished reacting. Diethyl malonate (116 ml, 105 mmol) and n-propylurea (10 g, 98 mmol) are then added and the mixture is stirred under reflux for 5 h. After conc. HCl (5 ml) and hot water (45 ml) have been added, the mixture is filtered and the filtrate is concentrated in vacuo. Ethanol is added to the residue and the mixture is stirred. The solid is filtered off with suction and dried.

後処理

  1. temperatureunder reflux for 5 h
  2. filtrationthe mixture is filtered
  3. concentrationthe filtrate is concentrated in vacuo
  4. additionEthanol is added to the residue
  5. stirringthe mixture is stirred
  6. filtrationThe solid is filtered off with suction
  7. customdried

出典と根拠

ORDレコード
ord-a5c35d0dd7fe4a1aa842846ec4e1bb61
出典データセット
uspto-grants-2010_06
特許番号
US07737144B2

関連ノート

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