Oxalyl chloride → N-[(1-Butyl-4-piperidinyl)methyl]5-chloro-2-methylbenzoxazole-7-carboxamide
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:12]([OH:14])=O)[C:5]2[O:9][C:8]([CH3:10])=[N:7][C:6]=2[CH:11]=1.C(Cl)(=O)C(Cl)=O.[CH2:21]([N:25]1[CH2:30][CH2:29][CH:28]([CH2:31][NH2:32])[CH2:27][CH2:26]1)[CH2:22][CH2:23][CH3:24]>C(N(CC)CC)C>[CH2:21]([N:25]1[CH2:30][CH2:29][CH:28]([CH2:31][NH:32][C:12]([C:4]2[C:5]3[O:9][C:8]([CH3:10])=[N:7][C:6]=3[CH:11]=[C:2]([Cl:1])[CH:3]=2)=[O:14])[CH2:27][CH2:26]1)[CH2:22][CH2:23][CH3:24]参加物
5
実験手順
5-Chloro-2-methylbenzoxazole-7-carboxylic acid (Ger. Offen. 2,225,544) is converted to its acid chloride by treatment with oxalyl chloride. The acid chloride is treated with N-(1-butyl-4-piperidinyl)methylamine in the presence of triethylamine to afford the title compound.