Chloroacetyl chloride → HCID 58574532、化合物
反応式
[NH2:1][CH2:2][C:3]1([CH3:15])[CH2:7][CH2:6][CH2:5][N:4]1[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].[Cl:16][CH2:17][C:18](Cl)=[O:19].C(N(C(C)C)CC)(C)C>C(Cl)Cl>[Cl:16][CH2:17][C:18]([NH:1][CH2:2][C:3]1([CH3:15])[CH2:7][CH2:6][CH2:5][N:4]1[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])=[O:19]参加物
5
実験手順
A solution of tert-butyl 2-(aminomethyl)-2-methylpyrrolidine-1-carboxylate (1.2 g), excess 2-chloroacetyl chloride (2 mL) and diisopropyl ethyl amine (2 mL) in DCM was stirred at room temperature for about 2 h. The reaction was monitored by LC-MS. After the solution was concentrated in vacuo, 0.7 g of the desired product was obtained by column chromatography purification. MS (ESI): 291, 293 (MH+).
後処理
- concentrationAfter the solution was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-929117189025436fb56aadf44eb7a0cc
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772301B2
反応ノート
読み込み中…